Description

Methyl (2R)-2-Fluoropropanoate is a high-purity chiral fluorinated building block essential for advanced organic synthesis. This compound matters for its role in introducing the fluorine atom and the (2R) stereocenter into target molecules, a critical step in developing pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated herbicides, fungicides, and insecticides where the fluorine atom improves efficacy and environmental profile.
• Asymmetric Synthesis: Serves as a versatile electrophile or building block in stereoselective reactions, including nucleophilic substitutions and cross-coupling reactions, to construct complex chiral molecules.
• Prosthetic Group & Labeling: Potential use in the synthesis of 18F-labeled PET (Positron Emission Tomography) tracers for medical imaging, given its fluoropropanoate structure.
• Liquid Crystal & Electronic Materials: Can be utilized as a precursor in the synthesis of fluorinated organic compounds for electronic applications and advanced material science.

Basic Information

Product Name	Methyl (2R)-2-Fluoropropanoate
CAS No.	146805-74-5
Molecular Formula	C4H7FO2
Molecular Weight	106.10 g/mol
Synonyms	(R)-Methyl 2-fluoropropanoate; (2R)-2-Fluoropropionic Acid Methyl Ester; Methyl (R)-(-)-2-fluoropropionate; (R)-(-)-2-Fluoropropionic Acid Methyl Ester; (R)-2-Fluoropropionic acid methyl ester; Methyl (R)-2-fluoropropanoate; (R)-Methyl 2-fluoropropionate; 2-Fluoropropanoic acid, methyl ester, (2R)-
EINECS	Contact for details

Quality Control

Our Methyl (2R)-2-Fluoropropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and GC/HPLC for chemical purity, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its high volatility, ensure containers are kept tightly sealed when not in use. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.