Description

9H-Fluoren-9-Ylmethyln-[(2S)-4-Methyl-1-Oxopentan-2-Yl]Carbamate is a specialized, optically active carbamate derivative of the fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is of critical importance in advanced organic synthesis, particularly in peptide chemistry, where it serves as a key chiral building block or protecting group reagent. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the synthesis of complex peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: As a chiral Fmoc-protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: A crucial building block in the research and development of novel therapeutic peptides and protein-based drugs.
• Bioconjugation Chemistry: Used in the site-specific modification of peptides and proteins for drug delivery systems and diagnostic agents.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in the stereoselective synthesis of complex organic molecules.
• Protecting Group Strategy: Specifically for the temporary protection of amine functionalities in multi-step synthetic routes.
• Academic & Industrial R&D: For fundamental research in medicinal chemistry, chemical biology, and material science.

Basic Information

Item	Detail
Product Name	9H-Fluoren-9-Ylmethyln-[(2S)-4-Methyl-1-Oxopentan-2-Yl]Carbamate
CAS No.	146803-42-1
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-L-leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine; Fmoc-Leu-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid; N-Fmoc-L-leucine; Fmoc-L-Leu; N-α-Fmoc-L-leucine; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 9H-Fluoren-9-Ylmethyln-[(2S)-4-Methyl-1-Oxopentan-2-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and IR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistent quality and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.