Description

(6R-Trans)-7-[(2,2-Dimethyl-1-Oxopropyl)Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2- is a high-purity, advanced pharmaceutical intermediate belonging to the cephalosporin class of β-lactam antibiotics. This compound is critical for the synthesis of next-generation antibiotic APIs, offering a key chiral building block for creating potent, broad-spectrum antimicrobial agents. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) focused on anti-infective drug development and production.

Application

• Key Intermediate for Cephalosporin Synthesis: Serves as a crucial precursor in the multi-step synthesis of advanced cephalosporin antibiotic active pharmaceutical ingredients (APIs).
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and structural optimization of novel β-lactam antibiotics with improved efficacy and resistance profiles.
• Process Chemistry & Scale-Up: Employed in process development and pilot-scale manufacturing of antibiotic candidates, enabling route scouting and optimization.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Academic & Institutional Research: Utilized in biochemical and microbiological studies to investigate mechanisms of bacterial cell wall synthesis and inhibition.

Basic Information

Product Name	(6R-Trans)-7-[(2,2-Dimethyl-1-Oxopropyl)Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-
CAS No.	146794-70-9
Molecular Formula	C13H19N3O3S
Molecular Weight	297.37 g/mol
Synonyms	(6R,7R)-7-[(R)-2-Amino-2-(1,1-dimethylethoxycarbonyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Pivaloyloxymethyl Ester (related protected form); 7-ACA Pivaloyloxymethyl Ester Derivative; Cephalosporin C-7 Side Chain Intermediate; tert-Butoxycarbonylamino Protected Cephalosporin Ester; (6R-trans)-7-[(2,2-Dimethylpropanoyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Derivative; β-Lactam Intermediate; Antibiotic Synthesis Building Block
EINECS	Contact for details

Quality Control

Our (6R-Trans)-7-[(2,2-Dimethyl-1-Oxopropyl)Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., Drug Master Files - DMFs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions (e.g., nitrogen atmosphere) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R,7R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.