Description

p-Glycoprotein 3 is a high-purity biochemical reference standard and research compound, identified by CAS No. 146704-14-5. This compound is of significant interest in advanced pharmaceutical research, particularly in the study of multidrug resistance mechanisms and membrane transport proteins. It is essential for researchers and developers in the fields of oncology, pharmacokinetics, and drug discovery. The material serves as a critical tool for in vitro assays, target validation, and the development of P-glycoprotein inhibitors.

Application

• Pharmaceutical R&D: Used as a reference standard in the study of P-glycoprotein-mediated drug efflux and multidrug resistance (MDR) in cancer cells.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel P-glycoprotein inhibitors and substrates.
• ADME-Tox Studies: A vital reagent for investigating Absorption, Distribution, Metabolism, Excretion, and Toxicity, specifically for compounds affected by P-gp transport.
• Biochemical Research: Serves as a key material for membrane protein studies, ATPase activity assays, and understanding transporter structure-function relationships.
• Academic Research: Utilized in university and institutional labs for fundamental research on cellular defense mechanisms and barrier functions (e.g., blood-brain barrier).
• Diagnostic Development: Potential use in developing diagnostic kits and probes for assessing P-glycoprotein expression levels in tissues.

Basic Information

Item	Detail
Product Name	p-Glycoprotein 3
CAS No.	146704-14-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	P-Glycoprotein 3; P-gp 3; Multidrug Resistance Protein 3; MDR-3; ABCB4; ATP-binding cassette sub-family B member 4; Phosphatidylcholine Translocator; Class III P-Glycoprotein
EINECS	Contact for details

Quality Control

Our p-Glycoprotein 3 is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and functional activity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to relevant quality management principles to ensure consistent supply for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures (typically 2-8°C or as specified on the label). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Biological Activity	Assay-specific
Water Content (KF)	≤ 1.0%
Solubility	Soluble in specified buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.