Description

(E/Z)-3-o-Methyl Entacapone is a key pharmaceutical intermediate and a structural analog of the active pharmaceutical ingredient Entacapone. This compound matters for its critical role in the research and development of catechol-O-methyltransferase (COMT) inhibitors, which are essential in the treatment of Parkinson's disease. Pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions need this high-purity intermediate for synthesis, process optimization, and analytical method development.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis and research of Entacapone and related COMT inhibitor drug candidates.
• Process Chemistry R&D: Used for developing and scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Serves as a critical standard for HPLC, LC-MS, and NMR analysis in quality control and method validation.
• Metabolite Studies: Employed in pharmacological and pharmacokinetic research to study drug metabolism pathways.
• Academic Research: A valuable tool in medicinal chemistry programs focused on neurodegenerative diseases.
• Custom Synthesis: Building block for the preparation of novel chemical entities and analogs for biological screening.

Basic Information

Product Name	(E/Z)-3-o-Methyl Entacapone
CAS No.	146698-91-1
Molecular Formula	C15H15N3O5
Molecular Weight	317.30 g/mol
Synonyms	(E/Z)-3-O-Methylentacapone; (E/Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 3-Methyl Ether; 2-Cyano-3-(4,5-dihydroxy-2-nitrophenyl)-N,N-diethyl-2-propenamide 3-Methyl Ether; 3-OMe Entacapone; Entacapone 3-O-Methyl Ether; (E/Z)-3-O-Methyl-Entacapone; 3-O-Methyl Entacapone Isomer Mixture
EINECS	Contact for details

Quality Control

Our (E/Z)-3-o-Methyl Entacapone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0% (Total of E/Z isomers)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.