Description

Acetyl-n-Dimethyl-Alpha,β-Dehydroleucinamide is a specialized synthetic amino acid derivative with a unique dehydroleucine backbone. This compound is valued for its role as a key chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used as a constrained, non-natural amino acid analog to study protein-protein interactions and develop enzyme inhibitors.
• Chemical Biology Probes: Employed in the design and construction of molecular probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Acts as a chiral synthon for constructing stereochemically complex molecules in medicinal chemistry programs.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development and exploring new synthetic routes.

Basic Information

Product Name	Acetyl-n-Dimethyl-Alpha,β-Dehydroleucinamide
CAS No.	146469-60-5
Molecular Formula	C10H18N2O2
Molecular Weight	198.26 g/mol
Synonyms	N-Acetyl-α,β-dehydroleucine N-methylamide; (E)-2-Acetamido-4-methyl-2-pentenoic acid N-methylamide; Dehydroleucinamide derivative; Ac-δ-Leu-NHMe; CAS 146469-60-5; α,β-Dehydroleucine derivative; N-Acetyl-2-amino-4-methyl-2-pentenoic acid methylamide
EINECS	Contact for details

Quality Control

Our Acetyl-n-Dimethyl-Alpha,β-Dehydroleucinamide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.