Description

Ethyl-3-Amino-4,4,4-Trifluorobutyrate Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its trifluoromethyl group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering unique steric and electronic properties. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and CNS-active compounds.
• Agrochemical Research: Used in developing novel fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Peptide Mimetics: Incorporated into peptide chains to create analogs with improved bioavailability and resistance to enzymatic degradation.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and reactivity of fluorine atoms in complex molecular architectures.
• Material Science: Potential monomer or modifier for specialty polymers with specific surface properties or optical characteristics.

Basic Information

Product Name	Ethyl-3-Amino-4,4,4-Trifluorobutyrate Hydrochloride
CAS No.	146425-31-2
Molecular Formula	C6H11F3NO2 • HCl
Molecular Weight	237.62 g/mol
Synonyms	Ethyl 3-Amino-4,4,4-trifluorobutanoate Hydrochloride; 3-Amino-4,4,4-trifluorobutyric Acid Ethyl Ester Hydrochloride; 4,4,4-Trifluoro-3-aminobutanoic Acid Ethyl Ester Hydrochloride; (R/S)-Ethyl 3-Amino-4,4,4-trifluorobutyrate HCl; Ethyl β-Amino-4,4,4-trifluorobutyrate Hydrochloride; ATFB-OEt • HCl; 3-ATB Ethyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl-3-Amino-4,4,4-Trifluorobutyrate Hydrochloride is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.