Description

Ribonucleoprotein K CAS NO 146410-60-8 is a critical heterogeneous nuclear ribonucleoprotein (hnRNP) involved in multiple aspects of nucleic acid metabolism. This protein plays a pivotal role in regulating gene expression at the transcriptional and post-transcriptional levels, making it an essential reagent for advanced life science research. It is primarily utilized by biopharmaceutical R&D teams and academic research institutions focused on cancer biology, virology, and RNA processing mechanisms.

Application

• Biochemical Research: Used as a key protein component in studies of RNA splicing, transcription, and translation regulation.
• Cancer Research: Investigated for its role in tumor progression and as a potential target for oncological studies due to its involvement in cell proliferation and apoptosis.
• Virology Studies: Employed in research on viral replication cycles, particularly for viruses that interact with host cell RNA-binding proteins.
• Protein-Protein & Protein-Nucleic Acid Interaction Assays: Serves as a critical substrate or binding partner in pull-down assays, EMSA (Electrophoretic Mobility Shift Assay), and co-immunoprecipitation experiments.
• Diagnostic Development: Potential use as an antigen or standard in the development of immunoassays for research purposes.
• Cell Signaling Pathway Analysis: Utilized to elucidate signaling cascades, particularly those involving kinase pathways that phosphorylate hnRNP proteins.

Basic Information

Product Name	Ribonucleoprotein K
CAS No.	146410-60-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	hnRNP K; Heterogeneous Nuclear Ribonucleoprotein K; Transformation Up-Regulated Nuclear Protein; TUNP; CSBP; DNA/RNA-binding protein K; p70; HNRPK; AUKS
EINECS	Contact for details

Quality Control

Our Ribonucleoprotein K is produced and tested under stringent quality management protocols. Each batch is characterized for identity, purity, and biological activity to ensure consistency and reliability for your research. A comprehensive Certificate of Analysis (COA), detailing specifications such as purity (by SDS-PAGE), concentration, endotoxin levels, and functional activity data, is provided with every shipment to support your compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or solution
Identification (SDS-PAGE/Western Blot)	Complies
Purity (SDS-PAGE)	> 90%
Protein Concentration	As per COA (typically 0.1-1.0 mg/mL)
Endotoxin Level	< 1.0 EU/μg protein
Biological Activity (Binding Assay)	Contact for details
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.