Description

Cyclopropanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-2,2-Dimethyl-, trans- (9Ci) is a high-purity, functionalized cyclopropane derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block, offering a rigid, three-membered ring scaffold with both amino and hydroxymethyl functional groups for precise molecular construction. Pharmaceutical and agrochemical research organizations need it for developing novel active ingredients, leveraging its unique stereochemistry and bifunctional nature to create complex, biologically active molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the cyclopropane ring contributes to biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The constrained cyclopropane ring is employed to replace peptide bonds or other motifs in medicinal chemistry to improve metabolic stability and potency.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry and material science research.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-2,2-Dimethyl-, trans- (9Ci)
CAS No.	146400-25-1
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(1R,3S)-1-Amino-3-(hydroxymethyl)-2,2-dimethylcyclopropanecarboxylic acid; trans-1-Amino-3-(hydroxymethyl)-2,2-dimethylcyclopropanecarboxylic acid; (1R,3S)-2,2-Dimethyl-3-(hydroxymethyl)cyclopropanecarboxylic acid, 1-amino-; Gabapentin Lactam Intermediate (related derivative); AHDC; Cyclopropane amino acid derivative
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-2,2-Dimethyl-, trans- (9Ci) adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification methods, to ensure compliance with research and cGMP-grade standards. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.