Description

tert-Butanesulfinamide is a high-value chiral sulfinamide reagent, widely recognized for its pivotal role in asymmetric synthesis. Its primary importance lies in serving as a highly effective chiral auxiliary and ammonia equivalent for the stereoselective synthesis of amines, a critical transformation in pharmaceutical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity building blocks for complex molecule construction.

Application

• As a versatile chiral auxiliary for the asymmetric synthesis of amines via sulfinimine (N-sulfinyl imine) chemistry.
• Key starting material in the preparation of pharmaceutical intermediates, particularly for active pharmaceutical ingredients (APIs) containing chiral amine centers.
• Used in the synthesis of agrochemicals and other specialty chemicals where enantiomeric purity is crucial for biological activity.
• Employed in academic and industrial research for methodological development in organic and medicinal chemistry.
• Facilitates the synthesis of natural products and complex molecules that incorporate nitrogen stereocenters.
• Acts as a ammonia synthon for the introduction of nitrogen functionality in a stereocontrolled manner.

Basic Information

Product Name	tert-Butanesulfinamide
CAS No.	146374-27-8
Molecular Formula	C₄H₁₁NOS
Molecular Weight	121.20 g/mol
Synonyms	2-Methyl-2-propanesulfinamide; (R)-(+)-tert-Butanesulfinamide; (S)-(-)-tert-Butanesulfinamide; tert-Butylsulfinamide; 2-Methylpropane-2-sulfinamide; t-Butanesulfinamide; tert-Butylsulfinylamine; N-Sulfinyl-tert-butylamine
EINECS	Contact for details

Quality Control

Our tert-Butanesulfinamide is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the exacting standards of advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profile. Our quality systems are designed to support cGMP and ISO compliant workflows for our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0% (for enantiomerically pure grades)
Melting Point	86 - 90 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.