Description

Flurazepam-n-Desalkylhydroxyl is a key benzodiazepine derivative and a significant metabolite of the sedative-hypnotic drug Flurazepam. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in forensic toxicology, clinical research, and the development of new therapeutic agents or diagnostic methods.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of Flurazepam and its metabolites in biological matrices.
• Metabolite Research: Essential for studying the metabolic pathways, bioavailability, and elimination profiles of Flurazepam in preclinical and clinical research.
• Forensic Toxicology: Used as an analytical standard in forensic labs to accurately identify and quantify benzodiazepine use in post-mortem and human performance testing.
• Method Development & Validation: Critical for developing, calibrating, and validating analytical methods using techniques like HPLC, LC-MS/MS, and GC-MS.
• Impurity Profiling: Employed in the quality control of active pharmaceutical ingredients (APIs) to identify and control related substance impurities.
• Pharmacological Studies: Used in research to investigate the structure-activity relationships (SAR) of benzodiazepines and their effects on the central nervous system.

Basic Information

Product Name	Flurazepam-n-Desalkylhydroxyl
CAS No.	146367-71-7
Molecular Formula	C₁₇H₁₄ClFN₂O₂
Molecular Weight	332.76 g/mol
Synonyms	7-Chloro-1-(2-fluoroethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-Hydroxyflurazepam; Flurazepam N-Desalkyl Hydroxy Metabolite; Flurazepam Metabolite II; Ro 07-9749/001; Fludiazepam Impurity; Flurazepam Related Compound A
EINECS	Contact for details

Quality Control

Our Flurazepam-n-Desalkylhydroxyl is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods, and levels of related substances. We adhere to relevant industry guidelines for reference standard materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.