Description

Fmoc-Thr(Tbdms)-Oh CAS NO 146346-82-9 is a protected amino acid derivative, specifically an Fmoc-protected threonine with a tert-butyldimethylsilyl (TBDMS) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential construction of peptides using Fmoc chemistry.
• Pharmaceutical Intermediates: Used in the research and production of therapeutic peptides, including hormones, antibiotics, and antiviral agents.
• Bioconjugation: Serves as a modified amino acid for introducing specific functional groups or labels into synthetic peptides.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive peptide leads.
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Custom Peptide Services: A staple raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Thr(Tbdms)-Oh
CAS No.	146346-82-9
Molecular Formula	C24H31NO5Si
Molecular Weight	441.60 g/mol
Synonyms	Fmoc-Threonine(t-Butyldimethylsilyl)-OH; N-(9-Fluorenylmethoxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine; Fmoc-L-Threonine(O-t-Butyldimethylsilyl); Fmoc-Thr(OtBuMe2Si)-OH; Fmoc-T(OTBDMS)-OH; N-α-Fmoc-O-(tert-butyldimethylsilyl)threonine; (2S,3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]butanoic acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Thr(Tbdms)-Oh is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for peptide synthesis. Our standard quality commitment includes comprehensive testing by HPLC, NMR, and MS to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.