Description

Neurotrophin-4, Human is a high-purity recombinant protein belonging to the neurotrophin family, essential for the development, maintenance, and function of neurons. This product is critical for advanced life science research and therapeutic development, offering a reliable tool for studying neuronal survival, differentiation, and synaptic plasticity. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in neuroscience, neuroregeneration, and drug discovery programs.

Application

• Neuroscience Research: Fundamental studies on neuronal cell survival, differentiation, and axonal guidance.
• Drug Discovery & Screening: Used as a target or reagent in assays for developing novel neuroprotective or neurodegenerative disease therapeutics.
• Cell Culture & Tissue Engineering: A key growth factor component in media for cultivating primary neurons and stem cell-derived neural lineages.
• Biochemical Assay Development: Serves as a standard or active component in ELISA, cell-based bioassays, and binding studies.
• Preclinical Studies: Investigation of potential therapeutic effects in animal models of neurological disorders and nerve injury.

Basic Information

Product Name	Neurotrophin-4, Human
CAS No.	146318-03-8
Molecular Formula	C432H700N124O130S10 (Approximate, for mature homodimer)
Molecular Weight	~14 kDa (monomer)
Synonyms	NT-4; NT4; NT-5; Neurotrophin-5; Neurotrophic Factor 5; Neurotrophin-4; BDNF-2; Brain-Derived Neurotrophic Factor 2; Recombinant Human Neurotrophin-4; rhNT-4; NT-4/5
EINECS	Contact for details

Quality Control

Our Neurotrophin-4, Human is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to a comprehensive suite of analytical tests, including SDS-PAGE, HPLC for purity assessment, and cell-based bioassays to confirm specific activity. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity, endotoxin levels, and biological potency.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (SDS-PAGE & HPLC)	≥ 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based Assay)	ED50 within defined range
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.