Description

Mpegn-Alkyne 2K, 5K, 10K, 20K CAS NO 146185-77-5 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal alkyne group, available in precise molecular weights of 2,000, 5,000, 10,000, and 20,000 Daltons. This compound is a critical building block for advanced bioconjugation and click chemistry applications, enabling the precise, site-specific modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceutical development, diagnostics, and advanced material science who require reliable, well-characterized linkers for creating targeted drug delivery systems, diagnostic probes, and functional hydrogels.

Application

• Bioconjugation and Click Chemistry: Acts as a heterobifunctional linker for coupling peptides, proteins, antibodies, and oligonucleotides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted reactions.
• PEGylation Reagent: Used to modify therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life in vivo.
• Diagnostic Probe Synthesis: Facilitates the labeling of targeting molecules (e.g., antibodies, aptamers) with imaging agents (fluorophores, radionuclides) for in vitro and in vivo diagnostics.
• Polymer and Hydrogel Functionalization: Serves as a macromonomer or crosslinker to introduce bio-orthogonal functionality into hydrogels, micelles, and other polymeric scaffolds for tissue engineering and controlled release.
• Surface Modification: Enables the creation of non-fouling, functionalized surfaces on nanoparticles, biosensors, and medical devices to improve biocompatibility and enable specific binding.
• ADC (Antibody-Drug Conjugate) Linker: Provides a stable, hydrophilic spacer between the antibody and cytotoxic payload, optimizing pharmacokinetics and therapeutic index.
• Lipid-Nanoparticle (LNP) Formulation: Used to functionalize lipid components for targeted delivery of nucleic acid therapeutics (e.g., mRNA, siRNA).

Basic Information

Product Name	Mpegn-Alkyne 2K, 5K, 10K, 20K
CAS No.	146185-77-5
Molecular Formula	Typically CnH2n+2Om (Variable based on PEG chain length 'n' and terminal group)
Molecular Weight	2,000 Da, 5,000 Da, 10,000 Da, 20,000 Da (nominal)
Synonyms	Alkyne-PEG; Propargyl-PEG; mPEG-Alkyne; α-Methoxy-ω-propargyl-poly(ethylene glycol); Poly(ethylene glycol) methyl ether propargyl ether; PEG-Alkyne; Alkyne-terminated PEG; Propargyloxy-PEG-methoxy
EINECS	Contact for details

Quality Control

Every batch of Mpegn-Alkyne is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure consistency and purity. Our quality protocol includes verification of molecular weight (by GPC or MALDI-TOF), functional group integrity, and quantification of critical impurities. Certificates of Analysis (COA) detailing purity, molecular weight distribution (PDI), endotoxin levels (where applicable), and residual solvent content are provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), consider aliquoting to minimize repeated exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Nominal Molecular Weight	2K, 5K, 10K, 20K
Molecular Weight Distribution (PDI, by GPC)	≤ 1.05 - 1.10 (Grade dependent)
Assay (Functional Group, by NMR)	≥ 95%
Purity (HPLC)	≥ 98%
Moisture Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin (LAL) *	< 10 EU/mg (For specific grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.