Description

Proto-Oncogene Protein Pbx3 CAS NO 146150-81-4 is a high-purity, biologically active protein critical for research in molecular biology and oncology. This product is essential for studying transcriptional regulation, cell differentiation, and the mechanisms underlying leukemia and other cancers. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on targeted cancer therapy development and fundamental gene expression studies.

Application

• Biomedical Research: Fundamental studies on the role of PBX3 in transcriptional regulation and hematopoietic development.
• Oncology Target Validation: Used as a key reagent in assays to validate PBX3 as a therapeutic target in acute myeloid leukemia (AML) and other malignancies.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify novel small-molecule inhibitors or modulators of PBX3 activity.
• Protein-Protein Interaction Studies: Essential for investigating interactions with HOX proteins and other transcriptional cofactors.
• Diagnostic Assay Development: Serves as a reference standard in the development of ELISA or other immunoassays for detecting PBX3 expression levels.
• Cell Signaling Pathway Analysis: A critical component in research models deciphering signaling pathways involved in cell proliferation and differentiation.

Basic Information

Product Name	Proto-Oncogene Protein Pbx3
CAS No.	146150-81-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PBX3; Pre-B-cell leukemia transcription factor 3; PBX homeobox 3; PBX3 protein; Homeobox protein PBX3; Proto-oncogene PBX3; CAS 146150-81-4
EINECS	Contact for details

Quality Control

Our Proto-Oncogene Protein Pbx3 is produced under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment via SDS-PAGE and HPLC, identity confirmation, and functional activity assays. A detailed Certificate of Analysis (COA) documenting purity, concentration, endotoxin levels, and storage buffer is provided with every shipment to support your research compliance and reproducibility requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed properly after each use.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Positive for PBX3
Protein Concentration	Provided on COA
Biological Activity	Assessed by functional assay (e.g., DNA-binding)
Endotoxin Level	< 1.0 EU/µg
Buffer Composition	Tris, NaCl, Glycerol, DTT, pH provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.