Description

Adhesion-Related Kinase CAS NO 146149-84-0 is a high-purity, biologically active small molecule inhibitor specifically targeting the Adhesion-Related Kinase (ARK) signaling pathway. This compound is critical for advanced biochemical research and pharmaceutical development, enabling precise modulation of cellular adhesion and migration processes. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, neurology, and cardiovascular disease research, where understanding ARK's role is essential for therapeutic discovery.

Application

• Biochemical Research: Used as a selective tool compound to study the structure, function, and signaling mechanisms of Adhesion-Related Kinase in vitro and in cell-based assays.
• Drug Discovery & Development: Serves as a key reference standard and pharmacophore model in high-throughput screening (HTS) campaigns and lead optimization for novel ARK-targeted therapeutics.
• Oncology Research: Investigated for its potential to inhibit tumor cell proliferation, invasion, and metastasis by blocking ARK-mediated pathways critical for cancer progression.
• Neurological Disease Models: Applied in research exploring ARK's role in neural development, synaptic plasticity, and diseases such as Alzheimer's and Parkinson's.
• Cardiovascular Research: Utilized to study the kinase's involvement in vascular remodeling, angiogenesis, and heart disease pathophysiology.
• Academic & Institutional Studies: A fundamental reagent for graduate and post-doctoral research focused on cell adhesion, cytoskeletal dynamics, and intracellular signaling cascades.

Basic Information

Product Name	Adhesion-Related Kinase CAS NO 146149-84-0
CAS No.	146149-84-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARK Inhibitor; Adhesion Related Kinase Inhibitor; ARK; FAK-related non-kinase; FRNK (related protein context); PTK2B inhibitor (related family); Cell adhesion kinase inhibitor; Focal adhesion kinase-2 inhibitor; Proline-rich tyrosine kinase 2B modulator; CAS 146149-84-0
EINECS	Contact for details

Quality Control

Every batch of our Adhesion-Related Kinase inhibitor is produced and tested under strict quality management protocols to ensure exceptional purity and batch-to-batch consistency suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and potency are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC50)	Reported per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.