Description

Pmel 17 Protein CAS NO 146149-52-2 is a specialized recombinant protein, also known as PMEL or gp100, which plays a crucial role in melanin biosynthesis. This protein is of significant interest for research and development in the fields of immunology and oncology. It is primarily utilized by biotechnology companies, academic research institutions, and pharmaceutical developers focused on cancer immunotherapy, diagnostic assay development, and fundamental cell biology studies.

Application

• Immunotherapy Research: As a key melanoma-associated antigen (MAA), it is used in the development and evaluation of T-cell therapies, cancer vaccines, and monoclonal antibodies.
• Diagnostic Development: Serves as a critical antigen in immunoassays (ELISA, Western Blot) for detecting autoimmune vitiligo or melanoma-specific immune responses.
• Biomarker Studies: Employed in research to understand melanosome formation, pigmentation pathways, and the role of PMEL in melanoma progression.
• Antigen Standard: Used as a purified reference standard for calibrating analytical instruments and validating assay performance in clinical and research settings.
• Cell Biology & Biochemistry: A tool for studying protein processing, amyloid fibril formation, and intracellular trafficking within melanocytes.

Basic Information

Product Name	Pmel 17 Protein
CAS No.	146149-52-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PMEL; gp100; Melanocyte protein Pmel 17; Silver locus protein homolog; Pre-melanosome protein; ME20; SI; D12S53E; PMEL17; GP100
EINECS	Contact for details

Quality Control

Our Pmel 17 Protein is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and biological activity checks where applicable. A detailed Certificate of Analysis (COA) documenting purity (by SDS-PAGE and/or HPLC), endotoxin levels, and concentration is provided with every shipment to guarantee it meets your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or solution
Identification (SDS-PAGE/Western Blot)	Conforms
Purity (SDS-PAGE)	> 90%
Purity (HPLC)	> 95%
Endotoxin Level	< 1.0 EU/µg
Protein Concentration	As per COA
Biological Activity	Assay-dependent; available upon request
Solubility	Soluble in PBS or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.