Description

13-Cis Acitretin o-β-D-Glucuronide is a major, pharmacologically relevant metabolite of the retinoid drug acitretin. This compound matters as a critical reference standard for analytical and bioanalytical research, enabling precise quantification and metabolic profiling in clinical and preclinical studies. It is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers involved in developing and monitoring retinoid-based therapies for dermatological conditions.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified standard for HPLC, LC-MS, and other analytical methods.
• Metabolite Identification & Profiling: Crucial for studying the pharmacokinetics, metabolism, and excretion pathways of Acitretin.
• Bioanalytical Method Development: Used to validate and calibrate assays for quantifying Acitretin and its metabolites in biological matrices (e.g., plasma, serum).
• Drug Impurity Testing: Serves as a known impurity or degradation product standard for Acitretin drug substance and product quality control.
• Preclinical & Clinical Research: Supports toxicology studies and clinical trial sample analysis to ensure patient safety and drug efficacy.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring characterization of drug metabolites.

Basic Information

Product Name	13-Cis Acitretin o-β-D-Glucuronide
CAS No.	146090-81-5
Molecular Formula	C28H36O9
Molecular Weight	516.58 g/mol
Synonyms	(13Z)-Acitretin β-D-Glucuronide; 13-cis-Acitretin Glucuronide; (2Z,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-9-oxo-2,4,6,8-nonatetraen-1-yl β-D-Glucopyranosiduronic Acid; Acitretin Glucuronide (13-cis isomer); Ro 13-7652/000 Glucuronide
EINECS	Contact for details

Quality Control

Our 13-Cis Acitretin o-β-D-Glucuronide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.