Description

Carboxy Pioglitazone (m-V) is a key pharmaceutical intermediate and reference standard, primarily used in the research and development of advanced therapeutic agents. This compound is critical for ensuring the quality, consistency, and regulatory compliance of drug substances and finished products. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on metabolic disease treatments and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Pioglitazone and related thiazolidinedione-class active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control testing (e.g., HPLC, LC-MS) in pharmaceutical analysis.
• Metabolic Disease Research: Serves as a key compound in preclinical and clinical research for studying Type 2 diabetes and insulin resistance mechanisms.
• Impurity Profiling: Employed as a certified reference material to identify, quantify, and control process-related impurities and degradation products.
• Regulatory Compliance: Supports drug registration dossiers by providing a qualified standard for stability studies and specification setting.
• Custom Synthesis: Acts as a starting material for the development of novel analogs and derivatives with potential therapeutic activity.

Basic Information

Product Name	Carboxy Pioglitazone (m-V)
CAS No.	146062-48-8
Molecular Formula	C19H20N2O3S
Molecular Weight	356.44 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione-5-carboxylic Acid; 5-Carboxy Pioglitazone; Pioglitazone Carboxylic Acid Metabolite (M-V); Pioglitazone-5-Carboxylic Acid; KRP-297 Metabolite; AD-4833 Metabolite; U-72107A Metabolite
EINECS	Contact for details

Quality Control

Our Carboxy Pioglitazone (m-V) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.