Description

Xpbc-Ercc-3 Protein CAS NO 146045-44-5 is a high-purity recombinant protein essential for advanced molecular biology and biochemical research. This product is critical for studies involving DNA damage response, nucleotide excision repair pathways, and protein-protein interaction assays. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical R&D departments developing novel therapeutic targets.

Application

• Biochemical Research Reagent: Used as a key component in in vitro studies of DNA repair mechanisms, particularly nucleotide excision repair (NER).
• Enzyme Activity Assays: Serves as a substrate or co-factor in enzymatic assays to study the activity of repair complexes like ERCC1-XPF.
• Diagnostic Development: Employed in the development and calibration of immunoassays and ELISA kits targeting DNA repair biomarkers.
• Protein Interaction Studies: Used in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map protein interaction networks.
• Pharmaceutical Screening: Acts as a target protein in high-throughput screening (HTS) platforms for identifying potential drug candidates that modulate DNA repair.
• Reference Standard: Provides a high-purity standard for quality control in the production of related biologics and research tools.

Basic Information

Product Name	Xpbc-Ercc-3 Protein
CAS No.	146045-44-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ERCC3 Protein; XPB Protein; Xeroderma Pigmentosum group B-complementing protein; Excision repair cross-complementation group 3 protein; TFIIH basal transcription factor complex helicase XPB subunit; RAD25 homolog; DNA repair protein complementing XP-B cells; ATP-dependent DNA helicase XPB; EC 3.6.4.12
EINECS	Contact for details

Quality Control

Our Xpbc-Ercc-3 Protein is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including SDS-PAGE, HPLC, and functional activity assays, to ensure high purity, identity, and biological activity. Certificates of Analysis (COA) detailing purity, endotoxin levels, and specific activity are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at expected molecular weight
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Confirmed by functional assay
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.