Description

(S)-2-Diphenylphosphino-2'-Methoxyl-1,1'-Binaphthyl CAS NO 145964-36-9 is a chiral, atropisomeric monophosphine ligand belonging to the MOP (Methoxy-substituted Phosphine) family. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed asymmetric reactions, which is critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This ligand is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand for asymmetric hydrogenation of olefins, ketones, and imines.
• Catalyst component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Heck reactions).
• Key reagent for enantioselective synthesis of active pharmaceutical ingredients (APIs) and natural products.
• Used in the development of chiral catalysts for industrial-scale fine chemical manufacturing.
• Research applications in asymmetric allylic substitution and hydrofunctionalization reactions.
• Critical for producing optically pure intermediates in agrochemical and fragrance production.

Basic Information

Product Name	(S)-2-Diphenylphosphino-2'-Methoxyl-1,1'-Binaphthyl
CAS No.	145964-36-9
Molecular Formula	C33H25OP
Molecular Weight	468.52 g/mol
Synonyms	(S)-MOP; (S)-2-(Diphenylphosphino)-2'-methoxy-1,1'-binaphthyl; (S)-2-Methoxy-2'-(diphenylphosphino)-1,1'-binaphthyl; (S)-2'-Methoxy-2-(diphenylphosphino)-1,1'-binaphthalene; (S)-2-(Diphenylphosphanyl)-2'-methoxy-1,1'-binaphthalene; (S)-2-Diphenylphosphanyl-2'-methoxy-1,1'-binaphthyl; (S)-MOP Ligand; (S)-MeO-MOP
EINECS	Contact for details

Quality Control

Our production of (S)-2-Diphenylphosphino-2'-Methoxyl-1,1'-Binaphthyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and key impurity profiles. We maintain ISO 9001 quality management standards, and our processes are designed to meet the exacting requirements of cGMP for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The storage area should be cool, dry, and well-ventilated. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.