Description

Oprelvekin CAS NO 145941-26-0 is a recombinant human interleukin-11 (rhIL-11) analog, a thrombopoietic growth factor engineered to stimulate the production of platelets. This compound is critical for managing thrombocytopenia, a condition characterized by abnormally low platelet counts, which is a common and serious complication of chemotherapy. It is primarily required by pharmaceutical manufacturers, biotechnology research facilities, and clinical laboratories involved in developing and producing therapeutics for oncology support care and hematological disorders.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in drugs designed to prevent severe thrombocytopenia.
• Oncology Supportive Care: Mitigation of chemotherapy-induced thrombocytopenia, helping to maintain treatment schedules and reduce bleeding risks.
• Biopharmaceutical Research: Used as a reference standard or biological tool in hematopoiesis and cytokine signaling pathway studies.
• Drug Formulation Development: Serves as a key component in the R&D of injectable formulations, lyophilized powders, and stability studies.
• Clinical Trial Material: Supplied as a high-purity compound for use in preclinical and clinical trial stages of new therapeutic agents.

Basic Information

Product Name	Oprelvekin
CAS No.	145941-26-0
Molecular Formula	C845H1343N223O243S9
Molecular Weight	Approx. 19,000 Da
Synonyms	Recombinant Human Interleukin-11; rhIL-11; IL-11; Neumega (brand name); Oprelvekin recombinant; Interleukin-11 (human clone pTNF64 protein); Thrombopoietic growth factor; 143923-57-9 (CAS for unmodified IL-11)
EINECS	Contact for details

Quality Control

Our Oprelvekin is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests including identity confirmation, purity assessment, and biological activity testing to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccants are recommended. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Biological Activity	Meets release criteria
Endotoxin	< 1.0 EU/mg
Residual Moisture (KF)	< 3.0%
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.