Description

1-Chloro-2-(2,2,2-Trifluoroethyl)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of a reactive chlorobenzene moiety and a stable trifluoroethyl group, enabling precise molecular modifications. This compound is essential for R&D chemists and process engineers in the pharmaceutical and agrochemical industries seeking to introduce lipophilic, electron-withdrawing motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoroethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing dielectric properties and emission characteristics.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to produce specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures common in material science and drug discovery.
• Fluorine-19 NMR Spectroscopy: Can be utilized as a reference standard or a chemical shift marker in 19F NMR due to its distinct fluorine signature.

Basic Information

Product Name	1-Chloro-2-(2,2,2-Trifluoroethyl)Benzene
CAS No.	145914-05-2
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	2-Chloro-α,α,α-trifluoroethylbenzene; 1-Chloro-2-(2,2,2-trifluoroethyl)benzene; 2-(2,2,2-Trifluoroethyl)chlorobenzene; o-Chloro-α,α,α-trifluoroethylbenzene; Benzene, 1-chloro-2-(2,2,2-trifluoroethyl)-; 2-Chlorobenzyltrifluoride; (2-Chlorophenyl)trifluoroethane
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and 1H/19F NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.