Description

Activating Transcription Factor 4 (ATF4) is a critical protein involved in the cellular integrated stress response (ISR) pathway. This compound, identified by CAS 145891-90-3, is essential for research into cellular adaptation mechanisms under conditions of endoplasmic reticulum stress, nutrient deprivation, and oxidative stress. It is a key reagent for scientists in pharmaceutical R&D, molecular biology, and biochemistry focused on oncology, neurodegenerative diseases, and metabolic disorders.

Application

• Biomedical Research: Fundamental studies on the unfolded protein response (UPR) and cellular stress signaling pathways.
• Drug Discovery & Target Validation: Screening and validation of novel therapeutics targeting the ATF4 pathway for cancer and metabolic diseases.
• Academic Research: Investigating the role of ATF4 in apoptosis, autophagy, and amino acid metabolism in various disease models.
• Diagnostic Development: Utilized as a standard or component in assay development for monitoring cellular stress biomarkers.
• Cell Culture & Protein Interaction Studies: Used in experiments to study protein-protein interactions and gene expression regulation.

Basic Information

Product Name	Activating Transcription Factor 4
CAS No.	145891-90-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ATF4; CREB-2; CREB2; Tax-responsive enhancer element-binding protein 67; TXREB67; Cyclic AMP-dependent transcription factor ATF-4; Activating transcription factor 4 (tax-responsive enhancer element B67)
EINECS	Contact for details

Quality Control

Our Activating Transcription Factor 4 is produced and handled under stringent quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment and biological activity verification, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) detailing specific lot data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE/Western Blot)	Conforms
Purity (SDS-PAGE)	> 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Functional Assay)	Contact for details
Solubility	Specified buffer solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.