Description

Mastoparan 17 CAS NO 145854-61-1 is a synthetic, amphiphilic peptide toxin derived from wasp venom, known for its potent biological activity as a G-protein activator. This compound is a critical research tool for studying cellular signaling pathways, particularly those involving phospholipase C and calcium mobilization. It is essential for researchers and developers in pharmacology, neuroscience, and cell biology who require high-purity, reliable biochemical reagents for mechanistic studies and drug discovery.

Application

• Biochemical Research: A standard tool for investigating G-protein coupled receptor (GPCR) signaling cascades and mast cell degranulation mechanisms.
• Neuroscience Studies: Used to probe neurotransmitter release, ion channel modulation, and neuronal calcium dynamics.
• Drug Discovery Screening: Serves as a positive control or challenge agent in assays designed to identify novel inhibitors of mast cell activation or G-protein interactions.
• Cell Biology & Immunology: Employed to study immune cell (e.g., mast cell, basophil) activation, histamine release, and inflammatory responses.
• Peptide Chemistry & Pharmacology: Used as a reference compound in structure-activity relationship (SAR) studies to design new peptide-based therapeutics.
• Academic & Industrial R&D: Fundamental reagent for basic research in university labs and for applied research in biotech and pharmaceutical companies.

Basic Information

Product Name	Mastoparan 17
CAS No.	145854-61-1
Molecular Formula	C78H131N25O20
Molecular Weight	1690.0 g/mol
Synonyms	Mastoparan 17; Mastoparan XVII; L-KKWKILKKVLKALL-NH2; Ile-Lys-Trp-Lys-Ile-Leu-Lys-Lys-Val-Leu-Lys-Ala-Leu-Leu-NH2; MP-17; Gs Protein Activator Mastoparan 17; Wasp Venom Peptide Mastoparan 17
EINECS	Contact for details

Quality Control

Our Mastoparan 17 is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized by HPLC, MS, and amino acid analysis to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels, supporting research requiring reproducible and reliable performance.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.