Description

Pyrrolidine, 1-(2,2-Dimethyl-1-Oxopropyl)-2-[(Diphenylphosphino)Methyl]-, (2S)- is a high-value, chiral organophosphorus ligand, specifically a phosphine-modified pyrrolidine derivative. This compound is critical for enabling highly selective and efficient catalytic transformations in advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of complex, optically active molecules. The (2S)- configuration provides the specific stereochemical control required for producing enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: Serving as a key chiral ligand in transition metal-catalyzed reactions, such as asymmetric hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: Enabling the stereoselective construction of chiral centers in the development of novel drug candidates and APIs.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, agrochemicals, and flavors & fragrances where high enantiomeric purity is required.
• Academic & Industrial Research: A valuable tool for methodology development in organic and organometallic chemistry research laboratories.
• Catalyst Screening Libraries: A component in high-throughput screening for the discovery of new catalytic systems.

Basic Information

Item	Details
Product Name	Pyrrolidine, 1-(2,2-Dimethyl-1-Oxopropyl)-2-[(Diphenylphosphino)Methyl]-, (2S)-
CAS No.	145818-29-7
Molecular Formula	C22H28NO2P
Molecular Weight	369.44 g/mol
Synonyms	(2S)-1-(2,2-Dimethylpropanoyl)-2-[(diphenylphosphino)methyl]pyrrolidine; (S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine; (S)-2-(Diphenylphosphanylmethyl)-1-(2,2-dimethylpropanoyl)pyrrolidine; (S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine; Chiral Pyrrolidine Phosphine Ligand; PPM-type Ligand; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our (2S)-1-(2,2-Dimethyl-1-oxopropyl)-2-[(diphenylphosphino)methyl]pyrrolidine is produced and tested under strict quality management protocols to ensure high chemical and chiral purity. Our products undergo rigorous quality testing, including chiral HPLC and NMR analysis, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and enantiomeric excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.