Description

5-Bromo-1,3-Difluoro-2-(2,2,2-Trifluoroethoxy)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine and fluorine substituents on a benzene ring with a trifluoroethoxy side chain, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance and durability.
• Polymer & Specialty Chemicals: Incorporated into the synthesis of specialty polymers, coatings, and surfactants to impart oil- and water-repellent (fluorinated) properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and material science research, enabling the exploration of novel chemical space.

Basic Information

Product Name	5-Bromo-1,3-Difluoro-2-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	145767-78-8
Molecular Formula	C8H4BrF5O
Molecular Weight	291.02 g/mol
Synonyms	2-Bromo-4,6-difluoro-1-(2,2,2-trifluoroethoxy)benzene; 1-Bromo-3,5-difluoro-2-(2,2,2-trifluoroethoxy)benzene; Benzene, 5-bromo-1,3-difluoro-2-(2,2,2-trifluoroethoxy)-; 145767-78-8; 5-Bromo-1,3-difluoro-2-(trifluoroethoxy)benzene; 2-(2,2,2-Trifluoroethoxy)-5-bromo-1,3-difluorobenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,3-Difluoro-2-(2,2,2-Trifluoroethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.