Description

Connexin 33 CAS NO 145717-22-2 is a synthetic peptide or small molecule inhibitor specifically designed to target the Connexin 33 (Cx33) gap junction protein. This compound is a critical research tool for investigating intercellular communication, cellular signaling pathways, and the physiological roles of specific connexin isoforms. It is primarily utilized by researchers and scientists in the fields of molecular biology, cardiology, and neuroscience for targeted studies on gap junction function and regulation.

Application

• Biomedical Research: Fundamental studies on the structure, function, and regulation of Connexin 33 (GJA1) gap junction channels.
• Cardiovascular Research: Investigation of cardiac conduction, arrhythmia mechanisms, and myocardial cell coupling where Cx33 is expressed.
• Neuroscience Research: Exploration of neuronal synchronization, synaptic plasticity, and glial network communication.
• Cell Signaling Studies: Used to modulate intercellular calcium waves, cAMP diffusion, and other second messenger signaling events.
• Drug Discovery: Serves as a reference compound or pharmacological tool in screening assays for novel gap junction modulators.
• Toxicology Studies: Assessing the impact of chemicals or environmental factors on gap junction intercellular communication (GJIC).

Basic Information

Product Name	Connexin 33
CAS No.	145717-22-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gap Junction α-1 Protein Inhibitor; Cx33 Inhibitor; GJA1 Inhibitor; Connexin-33 Peptide; Cx33 Peptide; Cx33 Blocking Peptide; Gap Junction Modulator 145717-22-2
EINECS	Contact for details

Quality Control

Our Connexin 33 is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure traceability and support your research compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.