Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methylpent-4-Enoic Acid is a specialized, non-natural amino acid derivative featuring a protected amine group and a reactive terminal alkene. This compound matters as a critical, high-purity building block for the controlled synthesis of complex peptides and peptidomimetics, enabling advanced research and development. It is primarily needed by pharmaceutical R&D teams, peptide synthesis specialists, and academic researchers working on novel therapeutic agents, drug discovery platforms, and bioactive molecule libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled, sequential assembly of custom peptide sequences, particularly those requiring methylated backbone modifications.
• Peptidomimetic Drug Discovery: Serves as a versatile scaffold for creating peptide-like molecules with enhanced metabolic stability, bioavailability, and target specificity.
• Conjugation & Bioconjugation: The terminal alkene functionality allows for site-specific modifications via click chemistry (e.g., thiol-ene reactions) for labeling, PEGylation, or attachment to other biomolecules.
• Combinatorial Chemistry Libraries: Used in the generation of diverse chemical libraries for high-throughput screening against biological targets.
• Research on Protein-Protein Interactions (PPIs): Incorporated into peptide probes designed to inhibit or modulate challenging PPIs involved in disease pathways.
• Synthesis of Constrained Peptides: The alkene group can be utilized in ring-closing metathesis (RCM) to introduce conformational constraints into peptide structures.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methylpent-4-Enoic Acid
CAS No.	145615-72-1
Molecular Formula	C23H23NO5
Molecular Weight	393.43 g/mol
Synonyms	Fmoc-N-Me-2-amino-4-methyl-4-pentenoic acid; Fmoc-N-methyl-2-amino-4-methylpent-4-enoic acid; Fmoc-N-Me-Ampa-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-2-amino-4-methyl-4-pentenoic acid; Nα-Fmoc-Nα-methyl-L-2-amino-4-methyl-4-pentenoic acid; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-4-methyl-4-pentenoic acid; Fmoc-N-Me-4-methylpent-4-enoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methylpent-4-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity essential for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, batch-to-batch consistency, and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.