Description

(+/-)-1''-Epi-Perindopril is a key stereoisomer and synthetic intermediate of the widely prescribed antihypertensive drug Perindopril. This compound is of critical importance for pharmaceutical research and development, particularly in the synthesis and analytical characterization of active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers engaged in cardiovascular drug development, process optimization, and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Perindopril and its related analogs.
• Research & Development: Used in pharmacological studies to investigate structure-activity relationships (SAR) of angiotensin-converting enzyme (ACE) inhibitors.
• Reference Standard: Serves as an analytical standard for method development and impurity profiling in API quality control.
• Process Chemistry: Employed in route scouting and scale-up optimization for the manufacturing of cardiovascular APIs.
• Metabolite Studies: Utilized in the research of drug metabolism and pharmacokinetics (DMPK) for Perindopril.

Basic Information

Product Name	(+/-)-1''-Epi-Perindopril
CAS No.	145513-33-3
Molecular Formula	C19H32N2O5
Molecular Weight	368.47 g/mol
Synonyms	(3S,5aS,9aS,10aS)-3-Methyl-1,2,3,4,5,5a,6,7,8,9,9a,10,10a,11-tetradecahydrocyclopenta[b]quinoline-3-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic acid (stereoisomer); Perindopril Impurity; Perindopril Epi Isomer; 1''-Epiperindopril; S-9780; (3S,5aS,9aS,10aS)-Octahydro-5a-methyl-1,2,3,4,5,5a,6,7,8,9,9a,10,10a,11-tetradecahydrocyclopenta[b]quinoline-3-carboxylic acid, compound with (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid (1:1).
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Quality Control

Our (+/-)-1''-Epi-Perindopril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.