Description

Boc-L-Isoleucine Thioamide is a protected amino acid derivative where the isoleucine side chain is modified with a thioamide group and the amine is protected with a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in advanced organic synthesis, particularly for the preparation of modified peptides and peptidomimetics with enhanced stability or specific binding properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to create non-hydrolyzable peptide analogs for studying enzyme inhibition and receptor-ligand interactions.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a specialized monomer for introducing thioamide linkages into peptide chains, altering their conformational and metabolic properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new compounds with optimized pharmacokinetic profiles.
• Bioconjugation: Can be utilized for labeling peptides or creating custom linkers in bioconjugate chemistry.
• Academic & Industrial R&D: A valuable reagent for chemical biology research and high-throughput screening libraries.

Basic Information

Item	Detail
Product Name	Boc-L-Isoleucine Thioamide
CAS No.	145491-31-2
Molecular Formula	C11H22N2O2S
Molecular Weight	246.37 g/mol
Synonyms	(2S,3S)-2-[(tert-Butoxycarbonyl)amino]-3-methylpentanethioamide; N-(tert-Butoxycarbonyl)-L-isoleucine thioamide; Boc-Ile-thioamide; Boc-L-Ile-Thioamide; tert-Butyl (1S,2S)-1-(carbamothioyl)-2-methylbutylcarbamate; N-Boc-L-isoleucine thioamide; Boc-Isoleucine thioamide
EINECS	Contact for details

Quality Control

Our Boc-L-Isoleucine Thioamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.