Description

(R)-3,5-Xylyl-Binap is a high-value, chiral bisphosphine ligand widely recognized for its exceptional performance in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, crucial for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity ligands to develop efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in active pharmaceutical ingredients (APIs) for cardiovascular, CNS, and antiviral drugs.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Cross-Coupling Reactions: Facilitates asymmetric cross-coupling processes for C-C and C-X bond formation with high stereocontrol.
• Academic & Industrial R&D: A vital tool for methodology development and exploring new catalytic cycles in academic laboratories and corporate research centers.
• Fine Chemical Production: Enables the commercial-scale manufacture of specialty flavors, fragrances, and electronic chemicals with defined chirality.

Basic Information

Product Name	(R)-3,5-Xylyl-Binap
CAS No.	145416-77-9
Molecular Formula	C44H32P2
Molecular Weight	622.67 g/mol
Synonyms	(R)-(-)-2,2'-Bis(di-3,5-xylylphosphino)-1,1'-binaphthyl; (R)-3,5-Dimethylphenyl-BINAP; (R)-3,5-Me2C6H3-BINAP; (R)-3,5-Xyl-BINAP; (R)-3,5-XylBINAP; (R)-3,5-Xyl-4-BINAP; (R)-3,5-XylBINAP Ligand; (R)-Bis(3,5-dimethylphenylphosphino)-1,1'-binaphthyl
EINECS	Contact for details

Quality Control

Every batch of (R)-3,5-Xylyl-Binap is manufactured and tested under strict quality management systems. We guarantee high chiral purity and chemical integrity through comprehensive analytical methods including HPLC, NMR, and specific rotation measurement. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications for use in cGMP and non-GMP applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.