Description

Pioglitazone n-Oxide is a key pharmaceutical intermediate and metabolite of the thiazolidinedione-class antidiabetic drug, Pioglitazone. Its primary value lies in enabling critical research and development activities, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on metabolic disease research and the development of high-purity drug substances.

Application

• Pharmaceutical Intermediate: Used in the synthesis and research of Pioglitazone and its related analogs.
• Metabolite Reference Standard: Serves as a critical analytical standard in bioanalytical studies for quantifying drug metabolites in biological matrices.
• Pharmacokinetic & Metabolic Research: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of thiazolidinedione drugs.
• Impurity Standard: Employed in the identification and quantification of oxidative degradation products in Pioglitazone drug substance and finished dosage forms.
• Active Pharmaceutical Ingredient (API) Development: Supports process development and scale-up for the manufacturing of related therapeutic agents.
• Biochemical Research: Used in studies investigating the mechanisms of action of peroxisome proliferator-activated receptor gamma (PPARγ) agonists.

Basic Information

Product Name	Pioglitazone n-Oxide
CAS No.	145350-09-0
Molecular Formula	C₁₉H₂₀N₂O₄S
Molecular Weight	372.44 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione 1-Oxide; Pioglitazone N-Oxide; Pioglitazone 1-Oxide; AD-4833 N-Oxide; U-72107 N-Oxide; Pioglitazone Metabolite M-7; Pioglitazone Metabolite IV
EINECS	Contact for details

Quality Control

Our Pioglitazone n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.