Description

Z-Arg(Boc)2-OH Cha is a high-purity, protected arginine derivative widely used as a critical building block in peptide synthesis. Its primary value lies in providing a controlled method for introducing the arginine residue while protecting its reactive guanidine side chain, which is essential for synthesizing complex peptides and peptidomimetics. This compound is particularly vital for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors engaged in developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of arginine into peptide chains using Fmoc or Boc chemistry.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation: Serves as a linker or functional handle for attaching peptides to other molecules, surfaces, or carriers in bioconjugation projects.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Utilized in academic and industrial labs to study protein-protein interactions, enzyme substrates, and signal transduction pathways.
• GMP Manufacturing: Suitable as a starting material or intermediate in the cGMP production of active pharmaceutical ingredients (APIs) for clinical and commercial use.

Basic Information

Product Name	Z-Arg(Boc)2-OH Cha
CAS No.	145315-39-5
Molecular Formula	C₂₆H₄₁N₅O₈
Molecular Weight	551.64 g/mol
Synonyms	N2-[(Benzyloxy)carbonyl]-N5,N5-bis(tert-butoxycarbonyl)-L-arginine; Z-Arg(Boc)2-OH; Nα-Cbz-Nω, Nω'-bis-Boc-L-arginine; Z-L-Arg(Boc)2-OH; Benzyl N-{[(2S)-5-[(tert-Butoxycarbonyl)amino]-1-[(tert-butoxycarbonyl)imino]pentyl]carbamoyl}carbamate; Nα-Carbobenzoxy-Nω,Nω'-bis(tert-butoxycarbonyl)-L-arginine; CBZ-Arg(BOC)2-OH; L-Arginine, N2-[(phenylmethoxy)carbonyl]-N5,N5-bis[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Z-Arg(Boc)2-OH Cha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production can support standards relevant to pharmaceutical development, including ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.