Description

(2S)-2-Amino-2-Methyl-3-(2-Naphthyl)Propanoic Acid is a chiral, non-proteinogenic amino acid derivative featuring a naphthyl side chain, which imparts unique steric and electronic properties. This compound matters as a sophisticated building block in pharmaceutical research and development, particularly for creating novel peptide-based therapeutics and enzyme inhibitors. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and neurology research.
• Peptidomimetic Design: Used to incorporate constrained, hydrophobic amino acid analogs into peptide chains to enhance metabolic stability, bioavailability, and target binding affinity.
• Enzyme Inhibitor Development: Serves as a core structure for designing potent and selective inhibitors of proteases and other enzymes.
• Asymmetric Synthesis Catalyst Ligand: Potential use as a precursor for chiral ligands or organocatalysts in asymmetric synthesis.
• Chemical Biology Research: Employed as a molecular probe to study protein-protein interactions and enzyme mechanisms due to its bulky, aromatic side chain.
• Material Science: Exploration as a monomer for constructing specialty polymers with specific chiral or optical properties.

Basic Information

Item	Details
Product Name	(2S)-2-Amino-2-Methyl-3-(2-Naphthyl)Propanoic Acid
CAS No.	145232-47-9
Molecular Formula	C₁₄H₁₅NO₂
Molecular Weight	229.27 g/mol
Synonyms	(S)-2-Amino-2-methyl-3-(naphthalen-2-yl)propanoic acid; (S)-2-Amino-2-methyl-3-(2-naphthyl)propionic acid; (S)-2-Amino-2-methyl-3-(2-naphthyl)propanoate; 2-Naphthylalanine derivative; (S)-α-Methyl-2-naphthalenealanine; (2S)-2-Amino-2-methyl-3-(naphthalen-2-yl)propanoic acid; L-2-Amino-2-methyl-3-(2-naphthyl)propanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-2-Methyl-3-(2-Naphthyl)Propanoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.