Description

Betaglycan CAS NO 145170-29-2 is a high-purity, recombinant protein widely recognized as a type III transforming growth factor-beta (TGF-β) receptor, also known as TGFβR3. This soluble co-receptor plays a critical role in modulating cellular signaling pathways by regulating the bioavailability and activity of TGF-β superfamily ligands. It is an essential research-grade biochemical for scientists in the fields of cell biology, oncology, and developmental biology. Key applications include use as a critical reagent in signal transduction studies, high-throughput screening assays, and the development of therapeutic strategies targeting the TGF-β pathway.

Application

• Biochemical Research: Fundamental studies on TGF-β signaling mechanisms, ligand-receptor interactions, and cellular response modulation.
• Drug Discovery & Development: A key tool in screening platforms for identifying novel inhibitors or modulators of the TGF-β pathway for therapeutic applications.
• Cancer Research: Investigation of tumor microenvironment, metastasis, and epithelial-mesenchymal transition (EMT) processes where TGF-β signaling is pivotal.
• Cell Culture & Assay Development: Used to supplement media or as a coating agent to study specific cellular behaviors in controlled in vitro environments.
• Protein-Protein Interaction Studies: Serves as a binding partner in assays like ELISA, surface plasmon resonance (SPR), or pull-down experiments to characterize binding affinities.
• Standards & Controls: Acts as a purified protein standard for quantitative immunoassays, Western blotting, and quality control in related bioproduction.

Basic Information

Product Name	Betaglycan
CAS No.	145170-29-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TGF-β Receptor Type III; TGFβR3; Transforming Growth Factor Beta Receptor III; Soluble TGF-β Receptor; Glycan; Betaglycan Core Protein; Proteoglycan Betaglycan; Cell Surface Chondroitin / Heparan Sulfate Proteoglycan
EINECS	Contact for details

Quality Control

Our Betaglycan is produced under stringent conditions to ensure high batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, endotoxin level determination, and functional activity verification in cell-based assays. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure desiccants are used in storage areas and containers are sealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Mass Spec)	Conforms
Endotoxin Level (LAL)	< 1.0 EU/μg
Biological Activity (Cell-based assay)	Conforms
Solubility	Soluble in PBS or appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.