Description

Rme1 Protein CAS NO 145139-16-8 is a high-purity recombinant protein of significant interest in advanced biochemical research and development. This protein plays a crucial role in cellular processes related to DNA repair and genome stability, making it a valuable tool for mechanistic studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology research, molecular biology, and the development of novel therapeutic targets.

Application

• Biochemical Research: Used as a key reagent in in vitro studies to elucidate mechanisms of DNA damage response and repair pathways.
• Target Validation: Serves as a target protein in high-throughput screening (HTS) assays for identifying potential small-molecule inhibitors or modulators.
• Enzymology Studies: Employed in kinetic and functional assays to study enzyme activity and protein-protein interactions within the MRN complex.
• Antibody Production: Acts as an antigen for the generation and purification of specific polyclonal or monoclonal antibodies.
• Diagnostic Development: Potential use as a component in developing diagnostic kits for conditions linked to DNA repair deficiencies.
• Cell Signaling Research: Investigated in studies focusing on cell cycle checkpoints and genomic integrity maintenance.

Basic Information

Item	Details
Product Name	Rme1 Protein
CAS No.	145139-16-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Recombination protein MRE11; MRE11 homolog; MRE11A; MRE11 homolog A; Meiotic recombination 11 homolog 1; MRE11 double-strand break repair nuclease; MRE11 nuclease; Rme1; hMRE11; ATLD
EINECS	Contact for details

Quality Control

Our Rme1 Protein is produced and tested under stringent conditions to ensure high purity, activity, and batch-to-batch consistency. Quality assurance includes analysis via SDS-PAGE, HPLC, and functional activity assays. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, biological activity, and endotoxin levels is provided with each batch to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Single major band at expected molecular weight
Purity (HPLC)	≥ 90%
Protein Concentration	As per COA (typically 0.1 - 1.0 mg/mL)
Biological Activity	Confirmed by functional assay (e.g., nuclease activity)
Endotoxin Level	< 1.0 EU/μg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.