Description

Salivary Plasminogen Activator Alpha 1, Desmodus Rotundus is a highly specific serine protease enzyme derived from the saliva of the common vampire bat (Desmodus rotundus). This compound is a potent and selective activator of plasminogen, playing a critical role in the study of fibrinolysis and thrombolytic mechanisms. It is an essential research-grade biochemical for pharmaceutical R&D, particularly in the development of novel antithrombotic and thrombolytic agents. Key applications include in vitro diagnostic assays, biochemical research, and as a reference standard in cardiovascular and hemostasis studies.

Application

• Biochemical Research & Enzyme Kinetics: Used as a model enzyme to study the plasminogen activation pathway, specificity, and catalytic mechanisms.
• Pharmaceutical R&D (Thrombolytics): Serves as a key reference compound and tool in the discovery and development of new clot-dissolving (thrombolytic) drugs.
• In Vitro Diagnostic (IVD) Assays: Employed as a critical reagent in diagnostic kits for measuring fibrinolytic activity, plasminogen levels, and related hemostasis parameters.
• Neuroscience Studies: Investigated for its potential neuroprotective effects and role in synaptic plasticity following stroke or ischemic events.
• Reference Standard: Used for quality control and calibration in laboratories manufacturing or testing related biopharmaceuticals.
• Cell Culture & Tissue Engineering: Applied in research to understand and modulate extracellular matrix remodeling and cell migration.

Basic Information

Product Name	Salivary Plasminogen Activator Alpha 1, Desmodus Rotundus
CAS No.	145137-38-8
Molecular Formula	Contact for details
Molecular Weight	~43-45 kDa (Glycoprotein)
Synonyms	DSPAα1; Desmoteplase; Vampire Bat Salivary Plasminogen Activator (v-PA); Bat-PA; Desmodus Salivary Plasminogen Activator; α-1 Desmoteplase; Fibrinolytic Enzyme from Desmodus rotundus; Recombinant Desmoteplase (when applicable)
EINECS	Contact for details

Quality Control

Our Salivary Plasminogen Activator Alpha 1 is produced and tested under stringent conditions to ensure high purity and consistent biological activity, suitable for research and diagnostic applications. Each batch is characterized for identity, purity, and specific activity. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by SDS-PAGE and HPLC), protein concentration, specific activity (in Ploug units or equivalent), and endotoxin levels is provided with every shipment to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized (freeze-dried) material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent loss of activity. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at ~43-45 kDa
Purity (HPLC)	≥ 95%
Specific Activity	≥ 80,000 IU/mg
Protein Content (Bradford)	≥ 90% of stated weight
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.