Description

Pokeweed Antiviral Protein (PAP) is a potent ribosome-inactivating protein (RIP) derived from the *Phytolacca americana* plant, known for its specific enzymatic activity against viral RNA. This compound is a critical research tool and a promising candidate for the development of novel antiviral therapeutics and immunoconjugates. It is essential for biotechnology and pharmaceutical R&D teams focused on virology, oncology, and targeted drug delivery systems.

Application

• Antiviral Research: Used as a model ribosome-inactivating protein to study mechanisms of viral inhibition and host-pathogen interactions.
• Immunotoxin Development: Serves as the toxic payload in the construction of antibody-drug conjugates (ADCs) and immunotoxins for targeted cancer therapy.
• Biochemical Studies: Employed in enzymatic assays to investigate protein synthesis inhibition and ribosomal function.
• Plant Defense Mechanism Research: Studied for its role in plant innate immunity and defense against pathogens.
• Diagnostic Reagent Component: May be utilized in the development of sensitive diagnostic assays for viral detection.
• Virology & Vaccine Adjuvant Research: Explored for its potential to enhance immune responses or as a component in antiviral strategies.

Basic Information

Product Name	Pokeweed Antiviral Protein
CAS No.	145113-06-0
Molecular Formula	Information available on request
Molecular Weight	~29 kDa (monomer)
Synonyms	PAP; Pokeweed Antiviral Protein (PAP-I); Phytolacca americana Antiviral Protein; Ribosome-Inactivating Protein 1 (RIP1) from Phytolacca americana; PAP1; Dodecandrin; Antiviral Protein from Pokeweed; Phytolacca Anti-Viral Protein
EINECS	Contact for details

Quality Control

Our Pokeweed Antiviral Protein is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for purity, identity, and enzymatic activity. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by SDS-PAGE and HPLC), protein concentration, endotoxin levels, and biological activity is provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture condensation. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Consistent with Pokeweed Antiviral Protein
Purity (HPLC)	≥ 95%
Protein Content (UV)	≥ 90%
Biological Activity (Cell-free assay)	IC50 provided on COA
Endotoxin (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.