Description

Rink Amide Linker CAS NO 145069-56-3 is a specialized, high-purity chemical reagent widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a robust, acid-labile anchoring point for the C-terminus of peptides, enabling efficient cleavage and high-yield production of peptide amides. This linker is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing peptide-based therapeutics, diagnostic agents, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serving as the foundational resin linker for the synthesis of C-terminal peptide amides, a critical modification for many bioactive peptides.
• Pharmaceutical Intermediate Production: Enabling the scalable manufacture of peptide active pharmaceutical ingredients (APIs) for therapeutic applications.
• Combinatorial Chemistry Libraries: Facilitating the high-throughput generation of diverse peptide amide libraries for drug discovery and screening.
• Bioconjugation and Probe Development: Used in the creation of labeled peptides, imaging probes, and peptide-drug conjugates where an amide terminus is required.
• Academic and Industrial Research: A staple reagent in laboratories focused on peptide chemistry, molecular biology, and chemical biology research.
• Custom Peptide Service Providers: A core component for CROs and CDMOs offering custom peptide synthesis services to clients.

Basic Information

Product Name	Rink Amide Linker
CAS No.	145069-56-3
Molecular Formula	C19H22N2O4
Molecular Weight	342.39 g/mol
Synonyms	4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic Acid; Fmoc-Rink Amide Linker; Rink Amide AM Resin Linker; Fmoc-4-[(R,S)-α-(2',4'-Dimethoxyphenyl)Fmoc-aminomethyl]phenoxyacetic Acid; Rink Amide SPPS Linker; PAL-PEG-PS Linker (related class); Fmoc-XAL Linker; 5-(9-Fluorenylmethoxycarbonylamino)-5-(4-methoxyphenyl)pentanoic Acid (common misnomer for related structure)
EINECS	Contact for details

Quality Control

Our Rink Amide Linker is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for reproducible peptide synthesis outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for research and cGMP manufacturing applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.