Description

Fmoc-L-Aspartic Acid 4-Methyl Ester is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled incorporation of aspartic acid while protecting the β-carboxylic acid side chain from unwanted reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, stepwise construction of peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules by providing a protected carboxylic acid handle for later activation.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic Research: Fundamental reagent for studying peptide structure, function, and folding in biochemistry and molecular biology laboratories.
• Production of Aspartame Analogs: Can be used as a precursor in the synthesis of modified sweeteners or flavor enhancers.

Basic Information

Product Name	Fmoc-L-Aspartic Acid 4-Methyl Ester
CAS No.	145038-53-5
Molecular Formula	C20H19NO6
Molecular Weight	369.37 g/mol
Synonyms	Fmoc-Asp(OMe)-OH; Fmoc-L-Asp(OMe)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-methyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-methyl ester; Fmoc-Aspartic acid β-methyl ester; Fmoc-Asp(OCH3)-OH; Nα-Fmoc-L-aspartic acid 4-methyl ester; Fmoc-Asp-OMe
EINECS	Contact for details

Quality Control

Our Fmoc-L-Aspartic Acid 4-Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality assurance protocols are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.