Description

Tx2 Neurotoxin is a potent, highly specific peptide toxin derived from the venom of the *Grammostola rosea* tarantula. This compound is a critical research tool for the selective inhibition of voltage-gated sodium channels, particularly the hNav1.7 subtype. It is essential for researchers in neuroscience and pharmacology requiring precise molecular probes for channel characterization, pain pathway research, and drug discovery. The product is supplied as a high-purity, lyophilized powder suitable for laboratory use.

Application

• Neuroscience Research: Selective probe for studying the function and distribution of voltage-gated sodium channels, especially Nav1.7, in neuronal circuits.
• Pain Research & Drug Discovery: Target validation and screening tool in the development of novel, non-opioid analgesics targeting sodium channels.
• Ion Channel Characterization: Used in electrophysiology (e.g., patch-clamp) and binding assays to determine channel kinetics and pharmacology.
• Biochemical Studies: Tool for investigating channel protein structure-function relationships and interaction sites.
• Toxicology & Venom Research: Reference standard for the study of spider venom components and their mechanisms of action.

Basic Information

Product Name	Tx2 Neurotoxin
CAS No.	145033-94-9
Molecular Formula	C184H282N52O53S7
Molecular Weight	~4210.9 g/mol
Synonyms	ProTx-II; β/ω-Theraphotoxin-Tp2a; Tx2-6; GsAF-II; hNav1.7 Inhibitor; Tarantula Toxin ProTx-II; Voltage-Gated Sodium Channel Blocker; ω-TRTX-Tp2a
EINECS	Contact for details

Quality Control

Our Tx2 Neurotoxin is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity, mass spectrometry for identity confirmation, and functional bioassays to validate potency. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, peptide content, and specific activity.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. The product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers, aliquoted, and stored at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Biological Activity (IC50)	Specified per batch (typically nM range vs. hNav1.7)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.