Description

Sarcolipin is a small, regulatory protein that plays a critical role in modulating calcium transport in muscle cells. Its primary function involves inhibiting the sarco/endoplasmic reticulum calcium ATPase (SERCA), which is essential for understanding muscle thermogenesis and metabolic regulation. This makes it a vital research compound for scientists in the fields of biochemistry, physiology, and metabolic disease research. Researchers utilize Sarcolipin CAS NO 145018-73-1 to investigate mechanisms of non-shivering thermogenesis, obesity, and muscle function.

Application

• Biochemical Research: Used as a key reagent to study the inhibition mechanism of the SERCA pump in skeletal and cardiac muscle.
• Metabolic Studies: Essential for investigating the role of calcium cycling in muscle-based thermogenesis and energy expenditure.
• Physiology Research: Applied in experiments to understand muscle fatigue, contractility, and calcium signaling pathways.
• Drug Discovery: Serves as a target or tool compound in screening programs aimed at developing therapies for metabolic disorders like obesity and diabetes.
• Academic & Institutional Use: Supplied to universities and research institutes for fundamental studies in molecular and cellular biology.
• Protein-Protein Interaction Studies: Utilized to characterize its binding interactions with SERCA and other regulatory proteins.

Basic Information

Product Name	Sarcolipin
CAS No.	145018-73-1
Molecular Formula	C142H238N42O43S
Molecular Weight	3180.7 g/mol
Synonyms	SLN; Sarcolipin (human); Sarcolipin peptide; ATP2A1 regulator; SERCA inhibitor protein; PLN homolog; UNII-9P3H4Y71WQ; 9P3H4Y71WQ
EINECS	Contact for details

Quality Control

Our Sarcolipin is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to relevant quality standards for research-grade biochemicals, ensuring reliable performance in sensitive experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.