Description

Boc-Pyr-Oet CAS NO 144978-12-1 is a specialized N-Boc protected amino acid derivative, specifically the ethyl ester of Boc-protected pyroglutamic acid. This compound is a crucial high-purity building block in modern organic synthesis, particularly for the construction of complex peptide chains and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of peptides containing pyroglutamic acid residues.
• Pharmaceutical Intermediates: Serves as a critical precursor in the research and production of active pharmaceutical ingredients (APIs) with potential neurological or metabolic activity.
• Bioconjugation & Probe Development: Used in the preparation of labeled peptides and molecular probes for biochemical and diagnostic research.
• Combinatorial Chemistry: Employed in library generation for high-throughput screening in drug discovery programs.
• Academic Research: A valuable reagent for studies in organic chemistry, medicinal chemistry, and chemical biology focused on amino acid and peptide chemistry.

Basic Information

Product Name	Boc-Pyr-Oet
CAS No.	144978-12-1
Molecular Formula	C₁₂H₁₉NO₅
Molecular Weight	257.28 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-L-pyroglutamic acid ethyl ester; (S)-5-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid ethyl ester; Boc-L-pyroglutamic acid ethyl ester; Boc-L-pyroglutamic acid O-ethyl ester; Ethyl (S)-1-((tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate; N-Boc-L-pyroglutamic acid ethyl ester; N-tert-Butoxycarbonyl-L-pyroglutamic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Boc-Pyr-Oet is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric purity, and impurity profiles. Our quality commitment aligns with the standards required for GMP and ISO compliant environments in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.