Description

(6-Bromo-Pyridin-3-Yl)-Acetonitrile is a versatile brominated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromine atom and a nitrile functional group, makes it an essential intermediate for constructing complex heterocyclic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials, liquid crystals, and polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nitrile Transformation Chemistry: The acetonitrile moiety can be further functionalized into amides, acids, or reduced to amines, expanding its utility in medicinal chemistry.

Basic Information

Product Name	(6-Bromo-Pyridin-3-Yl)-Acetonitrile
CAS No.	144873-99-4
Molecular Formula	C7H5BrN2
Molecular Weight	197.03 g/mol
Synonyms	2-(6-Bromopyridin-3-yl)acetonitrile; 3-Pyridineacetonitrile, 6-bromo-; 6-Bromo-3-pyridineacetonitrile; (6-Bromo-3-pyridyl)acetonitrile; 6-Bromonicotinonitrile (common misnomer, check structure); 2-(6-Bromo-3-pyridinyl)acetonitrile; 6-Bromopyridin-3-yl-acetonitrile
EINECS	Contact for details

Quality Control

Our (6-Bromo-Pyridin-3-Yl)-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation by IR and NMR, and levels of key impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.