Description

(S)-2-Diphenyphosphino-2'-Ethyl-1,1'-Binaphthyl is a high-value, chiral monophosphine ligand essential for asymmetric catalysis. Its unique binaphthyl backbone with a diphenylphosphino group and ethyl substituent provides excellent steric and electronic control, enabling highly enantioselective transformations. This compound is a critical component for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical outcomes in their synthetic processes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Asymmetric Cross-Coupling Reactions: Employed in C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to create chiral biaryl structures.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers via nucleophilic attack on allylic substrates with high enantiomeric excess.
• Catalyst Screening Libraries: Used in high-throughput screening for the discovery and optimization of new chiral catalytic systems.
• Academic & Industrial R&D: A fundamental tool for developing novel synthetic methodologies in organic and organometallic chemistry.
• Production of Chiral Active Pharmaceutical Ingredients (APIs): Enables the commercial-scale synthesis of enantiomerically pure drugs and their key intermediates.

Basic Information

Product Name	(S)-2-Diphenyphosphino-2'-Ethyl-1,1'-Binaphthyl
CAS No.	144868-17-7
Molecular Formula	C34H27P
Molecular Weight	466.55 g/mol
Synonyms	(S)-2-(Diphenylphosphino)-2'-ethyl-1,1'-binaphthyl; (S)-2-Ethyl-2'-(diphenylphosphino)-1,1'-binaphthyl; (S)-Et-BINAP; (S)-2'-Ethyl-2-(diphenylphosphino)-1,1'-binaphthyl; (S)-2-Ethyl-2'-(diphenylphosphino)-1,1'-binaphthyl; (S)-2-(Diphenylphosphino)-2'-ethyl-[1,1'-binaphthalene]; (S)-2'-Ethyl-2-diphenylphosphino-1,1'-binaphthyl; (S)-2-Ethyl-2'-(diphenylphosphino)-1,1'-binaphthalene
EINECS	Contact for details

Quality Control

Our (S)-2-Diphenyphosphino-2'-Ethyl-1,1'-Binaphthyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.