Description

(+)-(1R,2R)-O,n-Di-Desmethyl Tramadol Hcl is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for analytical research, method development, and the synthesis of novel active pharmaceutical ingredients (APIs) within the pharmaceutical and life sciences sectors. It is primarily utilized by research institutions, analytical laboratories, and manufacturers engaged in the development and quality control of analgesic and central nervous system (CNS) active compounds.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (e.g., HPLC, GC-MS) of related compounds in drug substances and finished products.
• Metabolite Research: Serves as a key analytical standard for studying the metabolic pathways and pharmacokinetics of tramadol and its analogs.
• Process Development & Validation: Employed in the development and validation of synthetic routes and purification processes for complex chiral molecules.
• Impurity Profiling: Essential for identifying, characterizing, and controlling potential genotoxic and other specified impurities in API manufacturing.
• Medicinal Chemistry Research: Acts as a building block or precursor in the synthesis of new chemical entities for pharmacological evaluation.
• Forensic & Clinical Toxicology: Used as a calibrant or control in assays designed to detect and quantify specific analytes in biological matrices.

Basic Information

Product Name	(+)-(1R,2R)-O,n-Di-Desmethyl Tramadol Hydrochloride
CAS No.	144830-18-2
Molecular Formula	C14H22ClNO2
Molecular Weight	271.79 g/mol
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride; O-Desmethyl Tramadol Metabolite; (+)-O-Desmethyltramadol HCl; M1 Tramadol Metabolite (HCl salt); (1R,2R)-Tramadol Metabolite O-Desmethyl; AR-R 15889AR; (1R,2R)-M1 Metabolite
EINECS	Contact for details

Quality Control

Our production of (+)-(1R,2R)-O,n-Di-Desmethyl Tramadol Hcl adheres to stringent in-process controls and final release testing to ensure identity, purity, and consistency. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing chromatographic purity, chiral purity, residual solvents, and other critical parameters. We operate under a quality management system designed to meet the exacting standards of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1R,2R)
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.