Description

(+)-(1R,2R)-o-Desmethyl Tramadol Hcl is a high-purity, enantiomerically pure active pharmaceutical intermediate (API) and reference standard. This compound is a key metabolite and synthetic precursor in the development and analytical validation of centrally acting analgesic pharmaceuticals. It is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the synthesis of novel pain management therapeutics or the production of high-quality reference materials.

Application

• Pharmaceutical Reference Standard: Used for method development, validation, and quality control (HPLC, GC-MS) in analytical laboratories.
• Active Pharmaceutical Intermediate (API): Serves as a critical chiral building block in the synthesis of advanced analgesic compounds and their derivatives.
• Metabolite Studies: Employed in pharmacological and toxicological research to study the metabolic pathways and activity of tramadol and related substances.
• Process Development & Optimization: Utilized in scaling up synthetic routes and improving the yield and purity of final pharmaceutical products.
• Regulatory Compliance & Documentation: Provides a certified material for generating impurity profiles and stability data required for regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	(+)-(1R,2R)-o-Desmethyl Tramadol Hydrochloride
CAS No.	144830-14-8
Molecular Formula	C15H23NO2•HCl
Molecular Weight	285.81 g/mol (as hydrochloride salt)
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; O-Desmethyltramadol (M1 Metabolite) HCl; (+)-O-Desmethyltramadol Hydrochloride; (1R,2R)-Tramadol Metabolite M1 HCl; (1R,2R)-M1; TR-M1 HCl; UNII-9K1I7R746M
EINECS	Contact for details

Quality Control

Our (+)-(1R,2R)-o-Desmethyl Tramadol Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing identity, purity (HPLC), and impurity profile data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (1R,2R enantiomer)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.