Description

Tnf-α(10-36) (Human) is a defined synthetic peptide fragment corresponding to residues 10-36 of the human Tumor Necrosis Factor Alpha (TNF-α) protein. This high-purity reference standard is critical for advanced biochemical research, enabling precise study of protein-protein interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on immunology, inflammation, and autoimmune disease mechanisms.

Application

• Biochemical Research: Used as a reference standard and competitive inhibitor in studies of TNF-α receptor binding and signaling cascades.
• Drug Discovery: Serves as a key tool compound for screening and validating novel anti-inflammatory and immunomodulatory therapeutics.
• Assay Development: Employed in the development and calibration of ELISA, SPR (Surface Plasmon Resonance), and other bioanalytical assays targeting TNF-α activity.
• Academic Studies: Facilitates fundamental research into the structure-function relationship of TNF-α and its role in cellular apoptosis and inflammation.
• Peptide Mapping: Acts as a specific fragment for mass spectrometry-based protein characterization and peptide mapping exercises.

Basic Information

Product Name	Tnf-α(10-36) (Human)
CAS No.	144796-70-3
Molecular Formula	C136H221N41O43
Molecular Weight	3086.5 g/mol
Synonyms	TNF-α (10-36), human; Tumor Necrosis Factor Alpha (10-36); TNF-α Fragment (10-36); hTNF-α (10-36); TNF-α Peptide (10-36); TNF-α Inhibitory Peptide; Tnf-α(10-36); CAS 144796-70-3
EINECS	Contact for details

Quality Control

Every batch of Tnf-α(10-36) (Human) is manufactured and tested under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and peptide content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Conforms to theoretical values
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.