Description

1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine--n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt) is a high-purity, functionalized phospholipid derivative designed for advanced bioconjugation and drug delivery applications. This compound is critical for creating stable, cleavable linkages in targeted therapeutic systems, such as antibody-drug conjugates (ADCs) and liposomal formulations. It is an essential reagent for pharmaceutical R&D, biotechnology, and advanced material science, enabling precise control over payload release mechanisms.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a heterobifunctional crosslinker, utilizing the pyridyldithio group for reversible disulfide bond formation with thiols on antibodies or proteins, and the activated ester for amine coupling to drug payloads.
• Functionalized Liposome & Nanoparticle Production: Incorporated into lipid bilayers to introduce reactive pyridyldithio groups onto the surface of vesicles for subsequent conjugation of targeting ligands (e.g., peptides, antibodies).
• Controlled Drug Delivery Systems: Enables the development of stimuli-responsive nanocarriers where the disulfide bond is cleaved in the reductive intracellular environment, triggering drug release.
• Protein & Peptide Modification: Used to introduce a hydrophobic anchor (via the DSPE moiety) or a cleavable linker onto biomolecules for membrane insertion or functional studies.
• Surface Functionalization of Biomaterials: Applied to modify surfaces with a reactive layer for the covalent immobilization of biomolecules in biosensor and diagnostic assay development.
• Research & Development: A key tool in academic and industrial laboratories for exploring novel bioconjugation strategies and next-generation nanomedicines.

Basic Information

Item	Details
Product Name	1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine--n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt)
CAS No.	144735-79-5
Molecular Formula	C46H84N2O9PS2Na
Molecular Weight	927.3 g/mol (approx.)
Synonyms	DSPE-PDP; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate]; DSPE-Pyridyldithiopropionate; PDP-DSPE; N-[3-(2-Pyridyldithio)propionyl]-1,2-distearoyl-sn-glycero-3-phosphoethanolamine Sodium Salt; Pyridyl Disulfide PEG-DSPE; Heterobifunctional DSPE-PEG-PDP; DSPE-PEG-Pyridyldithiopropionamide
EINECS	Contact for details

Quality Control

Our 1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine--n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt) is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development with cGMP-compliant documentation and scale-up capabilities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 85% (Pyridyldithio active group)
Solubility	Soluble in chloroform, DMSO; slightly soluble in ethanol; insoluble in water
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.